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Scanning Electron Micrograph (SEM) of
bacteria attached to surface by means of self-produced extracellular
polymeric substances (EPS).
Courtesy, J.W. Costerton |
Practical Implications
The extreme stickiness of extracellular matrix
material is being studied by researchers to develop "green" (natural)
adhesives.
Selected CBE Publications
EPS / Initial Attachment Events
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| A protein gel showing differences in gene
expression between planktonic (free-floating) bacteria and attached
bacteria (Lane 5) of the species Pseudomonas aeruginosa. Each dark band represents proteins produced as a result of gene
activity. The smaller proteins are able to migrate through the
matrix faster; thus they are at the bottom of the gel. Larger proteins
appear at the top (scale on left). Darker
bands indicate higher concentrations of proteins.
Courtesy, Hongwei Yu and J.W.
Costerton |
Practical Implications
Understanding which genes are up-regulated or down-regulated when
microbes come into contact with a surface may give scientists clues
about how to interrupt the sequence of gene activation, and so
affect cells' ability to attach to a surface.
This approach may be particularly valuable for use with implanted
medical devices, such as artificial joints.
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